Fibroblast growth factor-23 abolishes 1,25-dihydroxyvitamin D3-enhanced duodenal calcium transport in male mice
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چکیده
Pissared Khuituan, Jarinthorn Teerapornpuntakit, Kannikar Wongdee, Panan Suntornsaratoon, Nipaporn Konthapakdee, Jintana Sangsaksri, Chanakarn Sripong, Nateetip Krishnamra, and Narattaphol Charoenphandhu Center of Calcium and Bone Research, Department of Physiology, Physiology Graduate Program, and Department of Biology, Faculty of Science, Mahidol University, Bangkok; and Faculty of Allied Health Sciences, Burapha University, Chonburi, Thailand
منابع مشابه
Fibroblast growth factor-23 abolishes 1,25-dihydroxyvitamin D₃-enhanced duodenal calcium transport in male mice.
Despite being widely recognized as the important bone-derived phosphaturic hormone, whether fibroblast growth factor (FGF)-23 modulated intestinal calcium absorption remained elusive. Since FGF-23 could reduce the circulating level of 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃], FGF-23 probably compromised the 1,25(OH)₂D₃-induced intestinal calcium absorption. FGF-23 may also exert an inhibitory act...
متن کاملEffects of Single Vitamin D3 Injection (200,000 Units) on Serum Fibroblast Growth Factor 23 and Sclerostin Levels in Subjects with Vitamin D Deficiency
BACKGROUND Vitamin D deficiency remains common in all age groups and affects skeletal and non-skeletal health. Fibroblast growth factor 23 is a bone-derived hormone that regulates phosphate and 1,25-dihydroxyvitamin D homeostasis as a counter regulatory factor. 1,25-Dihydroxyvitamin D stimulates fibroblast growth factor 23 synthesis in bone, while fibroblast growth factor 23 suppresses 1,25-dih...
متن کاملPhosphorylation of the 1,25-dihydroxyvitamin D3 receptor. A primary event in 1,25-dihydroxyvitamin D3 action.
1,25-Dihydroxyvitamin D3 is believed to mediate the regulation of calcium metabolism by a steroid hormone receptor mechanism. We now demonstrate that phosphorylation of the 1,25-dihydroxyvitamin D3 receptor occurs rapidly in embryonic chick duodenal organ culture in response to 1,25-dihydroxyvitamin D3. Phosphorylation of the receptor is strongly induced within 1 h by 1,25-dihydroxyvitamin D3 a...
متن کاملIndependence of 1,25-dihydroxyvitamin D3-mediated calcium transport from de novo RNA and protein synthesis.
The administration of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) to rachitic chicks produces an increase in (a) RNA and protein synthesis, (b) calcium binding protein (CaBP) concentration, and (c) alkaline phosphatase activity in the duodenum. These events occur concomitantly with enhanced calcium transport. We inhibited RNA and protein synthesis in richitic chicks and measured the subsequent respo...
متن کاملRegulation of serum 1,25(OH)2Vitamin D3 levels by fibroblast growth factor
Gattineni J, Twombley K, Goetz R, Mohammadi M, Baum M. Regulation of serum 1,25(OH)2Vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4. Am J Physiol Renal Physiol 301: F371–F377, 2011. First published May 11, 2011; doi:10.1152/ajprenal.00740.2010.—Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone implicated in the pathogenesis of several hypophosph...
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تاریخ انتشار 2012